The Juvéderm Collection is one of the most well-known lines of FDA-approved injectable fillers. Manufactured by Allergan, Juvéderm fillers are made with hyaluronic acid (HA), a molecule found naturally in the skin that has a unique capacity to attract and retain moisture: it can hold up to 1,000 times its weight in water, which helps skin look plump, supple, and youthful.